Editorial
- Genes & Diseases,Volume 1, Issue 1,2014, Pages 87-105
- Bone Morphogenetic Protein (BMP) signaling in development and human diseases
- Richard N. Wang1,2, Jordan Green1,3, Zhongliang Wang2,4, Youlin Deng2,4, Min Qiao2,4, Michael Peabody5, Qian Zhang2,4, Jixing Ye2,6, Zhengjian Yan2,4, Sahitya Denduluri1,2, Olumuyiwa Idowu1,3, Melissa Li2, Christine Shen3, Alan Hu7, Rex C. Haydon5, Richard Kang8, James Mok9, Michael J. Lee10, Hue L. Luu11, Lewis L. Shi12
- 1.The University of Chicago Pritzker School of Medicine, Chicago, IL 60637, USA;2.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA;3.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60638, USA;4.Departments of Orthopaedic Surgery, Medicine, and Gynecology, the Affiliated Hospitals of Chongqing Medical University, Chongqing 400016, China;5.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60640, USA;6.School of Bioengineering, Chongqing University, Chongqing, China;7.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60639, USA;8.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60641, USA;9.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60642, USA;10.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60643, USA;11.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60644, USA;12.Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60645, USA
Abstract
Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially discovered for their ability to induce bone formation, BMPs are now known to play crucial roles in all organ systems. BMPs are important in embryogenesis and development, and also in maintenance of adult tissue homeostasis. Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects, highlighting the essential functions of BMPs. In this review, we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development. A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling.
Keywords
BMP signaling; Development; Genetics; Mouse knockout; Pathogenesis; Signal transduction
Copyright © 2014 Chongqing Medical University. Published by Elsevier B.V